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KMID : 1001020100080030133
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Korean Journal of Urological Oncology
2010 Volume.8 No. 3 p.133 ~ p.137
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Analysis of Survival and Prognostic Factors of Renal Cell Carcinoma with Bone Metastasis
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Kim Taek-Sang
Kang Soo-Hwan
Oh Jeong-Hyun
Rhew Hyun-Yul
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Abstract
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Purpose: For appropriate treatment strategies in renal cell carcinoma (RCC) with bone metastasis, information about survival and prognosis of these patients were required. However, the reports about prognosis of RCC patients with bone metastasis are rare in the literature. We reviewed the records of RCC patients with bone metastasis, analysed about survival and prognostic factors.
Materials and Methods : From January 2000 to December 2009, 73 patients presented with metastasis to bone secondary to RCC. We retrospectively reviewed their medical, radiologic, and nuclear medical records. As prognostic factor, we analysed age, sex, pathologic type and stage of primary RCC, metastasis to other organ, the interval between the diagnosis of RCC and bone metastasis, and orthopedic treatment of bone metastasis. The relationship between survival and each factors were analysed and we categorized all patient into two different groups for analyse the difference in survival duration.
Results: The median survival time from bone metastasis was 12 month, 34 survival rate at 1, 2 and 5 year were 39.7%, 23.3%, and 2.7%. In the multivariate analysis, prognostic factors correlated with longer survival were the absence of metastasis to other organ and orthopedic surgery of bony lesion.
Conclusions : As prognostic factors predicting survival, the absence of metastasis to other organ and orthopedic surgery of bony lesion were identified. These would offer the useful tools for predicting survival and prognosis, and making the treatment plan.
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KEYWORD
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Renal cell carcinoma, Metastasis, Prognosis
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